Application | Comment | Organism |
---|---|---|
pharmacology | the enzyme is a potential target in the treatment of allergic reactions | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amitriptyline | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a sphingomyelin + H2O | Mus musculus | - |
a ceramide + phosphocholine | a ceramide is an N-acylsphingosine | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mast cell | isolated from bone marrow or peritoneal lavage of gene-targeted mice lacking Asm and their wild-type littermates | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a sphingomyelin + H2O | - |
Mus musculus | a ceramide + phosphocholine | a ceramide is an N-acylsphingosine | ? |
Synonyms | Comment | Organism |
---|---|---|
acid sphingomyelinase | - |
Mus musculus |
ASM | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | - |
assay at | Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | stimulation of bone marrow-derived mast cells with antigen results in about 2.5fold induction of enzyme activity | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is a regulator of mast cell function, detailed overview. Degranulation of mast cells is stimulated by store-operated Ca2+-entry, while in other cell types, Ca2+-entry is modified by ceramide. Exogenously added ceramide has been shown to trigger mast cell apoptosis. Ceramide is produced from sphingomyelin by acid sphingomyelinase. Decrease in body temperature upon the induction of systemic anaphylaxis is significantly less pronounced in asm-/- mice than in asm+/+ mice | Mus musculus |