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Literature summary for 3.1.4.12 extracted from

  • Yang, W.; Schmid, E.; Nurbaeva, M.K.; Szteyn, K.; Leibrock, C.; Yan, J.; Schaller, M.; Gulbins, E.; Shumilina, E.; Lang, F.
    Role of acid sphingomyelinase in the regulation of mast cell function (2014), Clin. Exp. Allergy, 44, 79-90.
    View publication on PubMed

Application

Application Comment Organism
pharmacology the enzyme is a potential target in the treatment of allergic reactions Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
amitriptyline
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a sphingomyelin + H2O Mus musculus
-
a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mast cell isolated from bone marrow or peritoneal lavage of gene-targeted mice lacking Asm and their wild-type littermates Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a sphingomyelin + H2O
-
Mus musculus a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
-
Mus musculus
ASM
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
assay at Mus musculus

Expression

Organism Comment Expression
Mus musculus stimulation of bone marrow-derived mast cells with antigen results in about 2.5fold induction of enzyme activity up

General Information

General Information Comment Organism
physiological function the enzyme is a regulator of mast cell function, detailed overview. Degranulation of mast cells is stimulated by store-operated Ca2+-entry, while in other cell types, Ca2+-entry is modified by ceramide. Exogenously added ceramide has been shown to trigger mast cell apoptosis. Ceramide is produced from sphingomyelin by acid sphingomyelinase. Decrease in body temperature upon the induction of systemic anaphylaxis is significantly less pronounced in asm-/- mice than in asm+/+ mice Mus musculus