Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of the nezyme by siRNA, The TNF receptor 1 is migrated into the lipid raft in diethyl malate-treated cells or ASMase-overexpressing cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a sphingomyelin + H2O | Homo sapiens | - |
a ceramide + phosphocholine | a ceramide is an N-acylsphingosine | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bladder carcinoma cell | - |
Homo sapiens | - |
ECV-304 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a sphingomyelin + H2O | - |
Homo sapiens | a ceramide + phosphocholine | a ceramide is an N-acylsphingosine | ? | |
a sphingomyelin + H2O | 6-N-(7-nitro-benz-2-oxa-1,3-diazol-4-yl)aminosphingomyelin is used as substrate | Homo sapiens | a ceramide + phosphocholine | a ceramide is an N-acylsphingosine | ? |
Synonyms | Comment | Organism |
---|---|---|
acidic sphingomyelinase | - |
Homo sapiens |
aSMase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
assay at | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | electrophilic compounds such as diethyl malate, methyl mercury, and cigarette smoke extracts significantly enhanced the expression of acidic sphingomyelinase 6fold in bladder carcinoma ECV-304 cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | role for the enzyme in the acceleration of the production of TNF-induced interleukin-6 as a pro-inflammatory cytokine, electrophiles can potentiate inflammation response by up-regulating of ASMase expression following formation of lipid rafts. Expression of ASMase facilitates the clustering of TNFR1 in the lipid raft that in turn enhanced the sensibility of TNF-alpha for the production of interleukin-6 | Homo sapiens |