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Literature summary for 3.1.4.12 extracted from

  • Kumagai, T.; Ishino, T.; Nakagawa, Y.
    Acidic sphingomyelinase induced by electrophiles promotes proinflammatory cytokine production in human bladder carcinoma ECV-304 cells (2012), Arch. Biochem. Biophys., 519, 8-16.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information knockdown of the nezyme by siRNA, The TNF receptor 1 is migrated into the lipid raft in diethyl malate-treated cells or ASMase-overexpressing cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a sphingomyelin + H2O Homo sapiens
-
a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bladder carcinoma cell
-
Homo sapiens
-
ECV-304 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a sphingomyelin + H2O
-
Homo sapiens a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?
a sphingomyelin + H2O 6-N-(7-nitro-benz-2-oxa-1,3-diazol-4-yl)aminosphingomyelin is used as substrate Homo sapiens a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?

Synonyms

Synonyms Comment Organism
acidic sphingomyelinase
-
Homo sapiens
aSMase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens electrophilic compounds such as diethyl malate, methyl mercury, and cigarette smoke extracts significantly enhanced the expression of acidic sphingomyelinase 6fold in bladder carcinoma ECV-304 cells up

General Information

General Information Comment Organism
physiological function role for the enzyme in the acceleration of the production of TNF-induced interleukin-6 as a pro-inflammatory cytokine, electrophiles can potentiate inflammation response by up-regulating of ASMase expression following formation of lipid rafts. Expression of ASMase facilitates the clustering of TNFR1 in the lipid raft that in turn enhanced the sensibility of TNF-alpha for the production of interleukin-6 Homo sapiens