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Literature summary for 3.1.4.12 extracted from

  • Clarke, C.J.; Mediwala, K.; Jenkins, R.W.; Sutton, C.A.; Tholanikunnel, B.G.; Hannun, Y.A.
    Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase (2011), J. Biol. Chem., 286, 21565-21576.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Synonyms

Synonyms Comment Organism
neutral sphingomyelinase-2
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Homo sapiens
nSMase2
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens all-trans-retinoic acid induces nSMase2 up

General Information

General Information Comment Organism
metabolism all-trans-retinoic acid induction of nSMase2 stimulates an increase in ceramide levels followed by G0/G1 growth arrestin MCF-7 cells. nSMase2 siRNA significantly inhibits all-trans-retinoic acid effects on ceramide levels and growth arrest. Neither all-trans-retinoic acid stimulation nor nSMase2 overexpression have significant effects on classical cell cycle regulators such as p21/WAF1 or retinoblastoma. In contrast, all-trans-retinoic acid suppresses phosphorylation of ribosomal S6 kinase and its downstream targets S6 and eIF4B, which is significantly inhibited by nSMase2 siRNA. nSMase2 overexpression is sufficient to suppress S6K phosphorylation and signaling Homo sapiens
physiological function all-trans-retinoic acid regulation of nSMase2, overview Homo sapiens