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Literature summary for 3.1.4.12 extracted from

  • Osawa, Y.; Seki, E.; Kodama, Y.; Suetsugu, A.; Miura, K.; Adachi, M.; Ito, H.; Shiratori, Y.; Banno, Y.; Olefsky, J.M.; Nagaki, M.; Moriwaki, H.; Brenner, D.A.; Seishima, M.
    Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression (2011), FASEB J., 25, 1133-1144.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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Mus musculus C57/BL6J
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Rattus norvegicus
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Rattus norvegicus Sprague-Dawley
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary Rattus norvegicus
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liver
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Mus musculus
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Synonyms

Synonyms Comment Organism
acid sphingomyelinase
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Mus musculus
acid sphingomyelinase
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Rattus norvegicus
ASM
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Mus musculus
ASM
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Rattus norvegicus

General Information

General Information Comment Organism
malfunction glucose intolerance in ASM-/- mice Mus musculus
malfunction treatment with high-dose glucose increases glycogen deposition and lipid accumulation in wild-type hepatocytes but not in ASM-/- cells Rattus norvegicus
metabolism ASM induces up-regulation of glucose transporter 2 accompanied by suppression of AMP-activated protein kinase phosphorylation. Loss of sphingosine kinase-1 diminishes ASM-mediated AKT phosphorylation, but exogenous S1P induces AKT activation in hepatocytes. In contrast, SphK1 deficiency does not affect AMPK activation. The SphK/S1P pathway is required for ASM-mediated AKT activation but not for AMPK inactivation Mus musculus
metabolism ASM induces up-regulation of glucose transporter 2 accompanied by suppression of AMP-activated protein kinase phosphorylation. Loss of sphingosine kinase-1 diminishes ASM-mediated AKT phosphorylation, but exogenous S1P induces AKT activation in hepatocytes. In contrast, SphK1 deficiency does not affect AMPK activation. The SphK/S1P pathway is required for ASM-mediated AKT activation but not for AMPK inactivation Rattus norvegicus
physiological function acid sphingomyelinase regulates the homeostasis of sphingolipids, including ceramides and sphingosine-1-phosphate. ASM increases glucose uptake, glycogen deposition, and lipid accumulation through activation of AKT and glycogen synthase kinase-3beta. In addition, ASM induces up-regulation of glucose transporter 2 accompanied by suppression of AMP-activated protein kinase phosphorylation. ASM modulates AKT activation and AMPK inactivation, thus regulating glucose and lipid metabolism in the liver Mus musculus
physiological function acid sphingomyelinase regulates the homeostasis of sphingolipids, including ceramides and sphingosine-1-phosphate. ASM increases glucose uptake, glycogen deposition, and lipid accumulation through activation of AKT and glycogen synthase kinase-3beta. In addition, ASM induces up-regulation of glucose transporter 2 accompanied by suppression of AMP-activated protein kinase phosphorylation. ASM modulates AKT activation and AMPK inactivation, thus regulating glucose and lipid metabolism in the liver Rattus norvegicus