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Literature summary for 3.1.4.12 extracted from

  • Urbina, P.; Collado, M.I.; Alonso, A.; Goni, F.M.; Flores-Diaz, M.; Alape-Giron, A.; Ruysschaert, J.M.; Lensink, M.F.
    Unexpected wide substrate specificity of C. perfringens alpha-toxin phospholipase C (2011), Biochim. Biophys. Acta, 1808, 2618-2627.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cholesterol sphingomyelinase is enhanced by cholesterol and by lipids with an intrinsic negative curvature, e.g. phosphatidylethanolamine Clostridium perfringens
additional information no effect on activity by monosialic ganglioside GM3 and phospholipids Clostridium perfringens
phosphatidylethanolamine sphingomyelinase is enhanced by cholesterol and by lipids with an intrinsic negative curvature, e.g. phosphatidylethanolamine Clostridium perfringens

Cloned(Commentary)

Cloned (Comment) Organism
expression of alpha-toxin in Escherichia coli Clostridium perfringens

Inhibitors

Inhibitors Comment Organism Structure
ganglioside GT1b
-
Clostridium perfringens
Lysophospholipids
-
Clostridium perfringens
additional information no effect on activity by monosialic ganglioside GM3 and phospholipids Clostridium perfringens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a sphingomyelin + H2O Clostridium perfringens
-
a ceramide + choline phosphate
-
?
a sphingomyelin + H2O Clostridium perfringens 8-6
-
a ceramide + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Clostridium perfringens
-
-
-
Clostridium perfringens 8-6
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a sphingomyelin + H2O
-
Clostridium perfringens a ceramide + choline phosphate
-
?
a sphingomyelin + H2O
-
Clostridium perfringens 8-6 a ceramide + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
alpha-toxin
-
Clostridium perfringens
SMase
-
Clostridium perfringens
sphingomyelinase
-
Clostridium perfringens

General Information

General Information Comment Organism
additional information establishing enzyme activity in lipid vesicles, method development, overview. Both lipase activities are sensitive to vesicle size, but in opposite ways: while phospholipase C is higher with larger vesicles, sphingomyelinase activity is lower Clostridium perfringens
physiological function alpha-toxin, a major determinant of Clostridium perfringens toxicity, exhibits both phospholipase C and sphingomyelinase activities with distinct, but partially overlapping and interacting active sites Clostridium perfringens