Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.12 extracted from

  • Bao, X.; Ogawa, T.; Se, S.; Akiyama, M.; Bahtiar, A.; Takeya, T.; Ishida-Kitagawa, N.
    Acid sphingomyelinase regulates osteoclastogenesis by modulating sphingosine kinases downstream of RANKL signaling (2011), Biochem. Biophys. Res. Commun., 405, 533-537.
    View publication on PubMed
Search for more literature for 3.1.4.12

Protein Variants

Protein Variants Comment Organism
additional information generation of ASM knockdown cells by specific shRNA Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
 Mus musculus
-
macrophage
-
 Mus musculus
-
osteoclast
-
 Mus musculus
-
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a sphingomyelin + H2O
-
 Mus musculus a ceramide + choline phosphate
-
 ?

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
-
 Mus musculus
ASM
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus ASM is NFAT2-inducible up

General Information

General Information Comment Organism
physiological function acid sphingomyelinase catalyzes the cleavage of sphingomyelin to generate ceramide. Ceramide levels may be a determining factor in osteoclast formation. As ceramide levels are also regulated by sphingosine kinase, as well as ASM. ASM differentially regulates sphingosine kinase 1 and sphingosine kinase 2 expression, the sphingosine kinases show opposing effects on osteoclast formation Mus musculus