Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of ASM knockdown cells by specific shRNA | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | - |
Mus musculus | - |
macrophage | - |
Mus musculus | - |
osteoclast | - |
Mus musculus | - |
RAW-264.7 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a sphingomyelin + H2O | - |
Mus musculus | a ceramide + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acid sphingomyelinase | - |
Mus musculus |
ASM | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | ASM is NFAT2-inducible | up |
General Information | Comment | Organism |
---|---|---|
physiological function | acid sphingomyelinase catalyzes the cleavage of sphingomyelin to generate ceramide. Ceramide levels may be a determining factor in osteoclast formation. As ceramide levels are also regulated by sphingosine kinase, as well as ASM. ASM differentially regulates sphingosine kinase 1 and sphingosine kinase 2 expression, the sphingosine kinases show opposing effects on osteoclast formation | Mus musculus |