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Literature summary for 3.1.4.12 extracted from

  • Cheng, Y.; Liu, F.; Wu, J.; Zhang, Y.; Nilsson, A.; Duan, R.D.
    Ezetimibe inhibits expression of acid sphingomyelinase in liver and intestine (2009), Lipids, 44, 897-906.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-
intestine
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O
-
Rattus norvegicus N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
A-SMase
-
Homo sapiens
A-SMase
-
Rattus norvegicus
acid SMase
-
Homo sapiens
acid SMase
-
Rattus norvegicus
acid sphingomyelinase
-
Homo sapiens
acid sphingomyelinase
-
Rattus norvegicus
alk-SMase
-
Homo sapiens
alk-SMase
-
Rattus norvegicus
alkaline SMase
-
Homo sapiens
alkaline SMase
-
Rattus norvegicus
N-SMase
-
Homo sapiens
N-SMase
-
Rattus norvegicus
neutral sphingomyelinase
-
Homo sapiens
neutral sphingomyelinase
-
Rattus norvegicus

Expression

Organism Comment Expression
Homo sapiens acid SMase protein is decreased by 20% in both Hep-G2 and Caco-2 cells at 0.1 mM ezetimibe down
Rattus norvegicus acid SMase protein is decreased by 25% in the intestine and by 34% in the liver at 0.1 mM ezetimibe down
Homo sapiens ezetimibe up to 0.05 mM has no effects on acid phosphatase activity in both Hep-G2 and Caco-2 cells, no change of alkaline phosphatase activity is identified by ezetimibe additional information