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Literature summary for 3.1.4.12 extracted from

  • Zhang, Y.; Duan, R.D.
    Boswellic acid inhibits expression of acid sphingomyelinase in intestinal cells (2009), Lipids Health Dis., 8, 51.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
3-acetyl-11-keto-beta-boswellic acid 62% inhibition of acid SMase at 0.1 mM Homo sapiens
additional information 3-acetyl-11-keto-beta-boswellic acid does not inhibit neutral or alkaline SMase activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
Homo sapiens
-
intestine
-
Homo sapiens
-
intestine-407 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
acid SMase
-
Homo sapiens
acid sphingomyelinase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.05
-
acid SMase Homo sapiens 3-acetyl-11-keto-beta-boswellic acid

Expression

Organism Comment Expression
Homo sapiens 3-acetyl-11-keto-beta-boswellic acid inhibits expression of acid sphingomyelinase in intestinal cells at high concentration 3-acetyl-11-keto-beta-boswellic acid decreases both the mass of acid SMase protein and the mRNA levels of acid SMase in the cells down