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Literature summary for 3.1.4.12 extracted from

  • Wu, B.X.; Rajagopalan, V.; Roddy, P.L.; Clarke, C.J.; Hannun, Y.A.
    Identification and characterization of murine mitochondrial-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5 (2010), J. Biol. Chem., 285, 17993-18002.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
cardiolipin enzymatic activity is induced 23fold at 0.1 mM Mus musculus
additional information phosphatidic acid, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol have minimal effects on MA-nSMase activity Mus musculus
phosphatidylglycerol enzymatic activity is induced 8fold at 0.1 mM Mus musculus
phosphatidylserine enzymatic activity is induced 15fold at 0.1 mM Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells and MCF-7 cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Mus musculus 5783
-
mitochondrion
-
Mus musculus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ absolute requirement for cations such as Mg2+ and Mn2+ Mus musculus
Mn2+ absolute requirement for cations such as Mg2+ and Mn2+ Mus musculus
additional information Ca2+, Co2+, Fe2+, or Zn2+ do not support MA-nSMase activity Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
SDS-PAGE Mus musculus
53870
-
calculated from amino acid sequence Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus D6MZJ6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
epididymis
-
Mus musculus
-
pancreas
-
Mus musculus
-
testis
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Mus musculus N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
MA-nSMase
-
Mus musculus
mitochondrial-associated neutral sphingomyelinase
-
Mus musculus
SMPD
-
Mus musculus
sphingomyelin phosphodiesterase 5
-
Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
the MA-nSMase has no acid SMase activity Mus musculus

pI Value

Organism Comment pI Value Maximum pI Value
Mus musculus calculated from amino acid sequence
-
8.6