Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cardiolipin | enzymatic activity is induced 23fold at 0.1 mM | Mus musculus | |
additional information | phosphatidic acid, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol have minimal effects on MA-nSMase activity | Mus musculus | |
phosphatidylglycerol | enzymatic activity is induced 8fold at 0.1 mM | Mus musculus | |
phosphatidylserine | enzymatic activity is induced 15fold at 0.1 mM | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expressed in HEK-293 cells and MCF-7 cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | absolute requirement for cations such as Mg2+ and Mn2+ | Mus musculus | |
Mn2+ | absolute requirement for cations such as Mg2+ and Mn2+ | Mus musculus | |
additional information | Ca2+, Co2+, Fe2+, or Zn2+ do not support MA-nSMase activity | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
SDS-PAGE | Mus musculus |
53870 | - |
calculated from amino acid sequence | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | D6MZJ6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
epididymis | - |
Mus musculus | - |
pancreas | - |
Mus musculus | - |
testis | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | - |
Mus musculus | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MA-nSMase | - |
Mus musculus |
mitochondrial-associated neutral sphingomyelinase | - |
Mus musculus |
SMPD | - |
Mus musculus |
sphingomyelin phosphodiesterase 5 | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
the MA-nSMase has no acid SMase activity | Mus musculus |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Mus musculus | calculated from amino acid sequence | - |
8.6 |