Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3,5-tri-O-dodecylsulfonyl-D_myo-inositol | - |
Rattus norvegicus | |
1,3,5-tri-O-ethylsulfonyl-D-myo-inositol | - |
Rattus norvegicus | |
1,3,5-tri-O-methylsulfonyl-D-myo-inositol | - |
Rattus norvegicus | |
1,3,5-tri-O-octylsulfonyl-D-myo-inositol | - |
Rattus norvegicus | |
1-O-dodecylsulfonyl-D-myo-inositol 3,5-bisphosphate | - |
Rattus norvegicus | |
1-O-ethylsulfonyl-D-myo-inositol 3,5-bisphosphate | - |
Rattus norvegicus | |
1-O-hexylsulfonyl-D-myo-inositol 3,5-bisphosphate | - |
Rattus norvegicus | |
1-O-methylsulfonyl-D-myo-inositol 3,5-bisphosphate | - |
Rattus norvegicus | |
1-O-octylsulfonyl-D-myo-inositol 3,5-bisphosphate | - |
Rattus norvegicus | |
cis, cis-cyclohexane 1,3,5-trisphosphate | barely inhibits aSMase even at a 0.1 mM concentration | Rattus norvegicus | |
myo-inositol 1,3,5-trisphosphate | - |
Rattus norvegicus | |
myo-Inositol 3,5-bisphosphate | - |
Rattus norvegicus | |
phosphatidyl inositol 3,5-bisphosphate | potent selective acid sphingomyelinase inhibitor | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Mono Q column chromatography, gel filtration | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | - |
Rattus norvegicus | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acid sphingomyelinase | - |
Rattus norvegicus |
aSMase | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0009 | - |
in 100 mM NaOAc, pH 5.2, at 37°C | Rattus norvegicus | 1-O-dodecylsulfonyl-D-myo-inositol 3,5-bisphosphate | |
0.00093 | - |
in 100 mM NaOAc, pH 5.2, at 37°C | Rattus norvegicus | phosphatidyl inositol 3,5-bisphosphate | |
0.004 | - |
in 100 mM NaOAc, pH 5.2, at 37°C | Rattus norvegicus | 1-O-octylsulfonyl-D-myo-inositol 3,5-bisphosphate | |
0.0267 | - |
in 100 mM NaOAc, pH 5.2, at 37°C | Rattus norvegicus | myo-inositol 1,3,5-trisphosphate | |
0.043 | - |
in 100 mM NaOAc, pH 5.2, at 37°C | Rattus norvegicus | 1-O-hexylsulfonyl-D-myo-inositol 3,5-bisphosphate | |
0.1 | - |
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C | Rattus norvegicus | cis, cis-cyclohexane 1,3,5-trisphosphate | |
0.1 | - |
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C | Rattus norvegicus | 1,3,5-tri-O-methylsulfonyl-D-myo-inositol | |
0.1 | - |
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C | Rattus norvegicus | 1,3,5-tri-O-ethylsulfonyl-D-myo-inositol | |
0.1 | - |
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C | Rattus norvegicus | 1,3,5-tri-O-octylsulfonyl-D-myo-inositol | |
0.1 | - |
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C | Rattus norvegicus | 1,3,5-tri-O-dodecylsulfonyl-D_myo-inositol | |
0.1 | - |
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C | Rattus norvegicus | myo-Inositol 3,5-bisphosphate | |
0.1 | - |
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C | Rattus norvegicus | 1-O-methylsulfonyl-D-myo-inositol 3,5-bisphosphate | |
0.1 | - |
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C | Rattus norvegicus | 1-O-ethylsulfonyl-D-myo-inositol 3,5-bisphosphate |