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Literature summary for 3.1.4.12 extracted from

  • Roth, A.G.; Redmer, S.; Arenz, C.
    Potent inhibition of acid sphingomyelinase by phosphoinositide analogues (2009), ChemBioChem, 10, 2367-2374.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,3,5-tri-O-dodecylsulfonyl-D_myo-inositol
-
Rattus norvegicus
1,3,5-tri-O-ethylsulfonyl-D-myo-inositol
-
Rattus norvegicus
1,3,5-tri-O-methylsulfonyl-D-myo-inositol
-
Rattus norvegicus
1,3,5-tri-O-octylsulfonyl-D-myo-inositol
-
Rattus norvegicus
1-O-dodecylsulfonyl-D-myo-inositol 3,5-bisphosphate
-
Rattus norvegicus
1-O-ethylsulfonyl-D-myo-inositol 3,5-bisphosphate
-
Rattus norvegicus
1-O-hexylsulfonyl-D-myo-inositol 3,5-bisphosphate
-
Rattus norvegicus
1-O-methylsulfonyl-D-myo-inositol 3,5-bisphosphate
-
Rattus norvegicus
1-O-octylsulfonyl-D-myo-inositol 3,5-bisphosphate
-
Rattus norvegicus
cis, cis-cyclohexane 1,3,5-trisphosphate barely inhibits aSMase even at a 0.1 mM concentration Rattus norvegicus
myo-inositol 1,3,5-trisphosphate
-
Rattus norvegicus
myo-Inositol 3,5-bisphosphate
-
Rattus norvegicus
phosphatidyl inositol 3,5-bisphosphate potent selective acid sphingomyelinase inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Mono Q column chromatography, gel filtration Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Rattus norvegicus N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
-
Rattus norvegicus
aSMase
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0009
-
in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1-O-dodecylsulfonyl-D-myo-inositol 3,5-bisphosphate
0.00093
-
in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus phosphatidyl inositol 3,5-bisphosphate
0.004
-
in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1-O-octylsulfonyl-D-myo-inositol 3,5-bisphosphate
0.0267
-
in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus myo-inositol 1,3,5-trisphosphate
0.043
-
in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1-O-hexylsulfonyl-D-myo-inositol 3,5-bisphosphate
0.1
-
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus cis, cis-cyclohexane 1,3,5-trisphosphate
0.1
-
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1,3,5-tri-O-methylsulfonyl-D-myo-inositol
0.1
-
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1,3,5-tri-O-ethylsulfonyl-D-myo-inositol
0.1
-
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1,3,5-tri-O-octylsulfonyl-D-myo-inositol
0.1
-
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1,3,5-tri-O-dodecylsulfonyl-D_myo-inositol
0.1
-
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus myo-Inositol 3,5-bisphosphate
0.1
-
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1-O-methylsulfonyl-D-myo-inositol 3,5-bisphosphate
0.1
-
IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1-O-ethylsulfonyl-D-myo-inositol 3,5-bisphosphate