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Literature summary for 3.1.4.12 extracted from

  • Roth, A.G.; Redmer, S.; Arenz, C.
    Development of carbohydrate-derived inhibitors of acid sphingomyelinase (2010), Bioorg. Med. Chem., 18, 939-944.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
6-O-dodecylsulfonyl-D-glucose 2,4-bisphosphate
-
Rattus norvegicus
6-O-ethylsulfonyl-D-glucose 2,4-bisphosphate
-
Rattus norvegicus
6-O-hexylsulfonyl-D-glucose 2,4-bisphosphate
-
Rattus norvegicus
6-O-octylsulfonyl-D-glucose 2,4-bisphosphate
-
Rattus norvegicus
phosphatidylinositol 3,5-bisphosphate potent inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Mono Q column chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Rattus norvegicus N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
-
Rattus norvegicus
aSMase
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00044
-
in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 6-O-dodecylsulfonyl-D-glucose 2,4-bisphosphate
0.00234
-
in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 6-O-octylsulfonyl-D-glucose 2,4-bisphosphate
0.00416
-
in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 6-O-hexylsulfonyl-D-glucose 2,4-bisphosphate
0.0396
-
in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 6-O-ethylsulfonyl-D-glucose 2,4-bisphosphate