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Literature summary for 3.1.4.12 extracted from

  • Smith, E.L.; Schuchman, E.H.
    Acid sphingomyelinase overexpression enhances the antineoplastic effects of irradiation in vitro and in vivo (2008), Mol. Ther., 16, 1565-1571.
    View publication on PubMed

Application

Application Comment Organism
medicine recombinant human ASM has little or no effect on the growth of tumor cells at pH 7.4 even in combination with irradiation, however when the culture media is acidified to pH 6.5 to mimic the acidic microenvironment of solid tumors, ASM-mediated cell death is markedly enhanced when combined with irradiation Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus B16-F10 melanoma cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
-
Homo sapiens
aSMase
-
Homo sapiens