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Literature summary for 3.1.4.12 extracted from

  • Clarke, C.J.; Guthrie, J.M.; Hannun, Y.A.
    Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells (2008), Mol. Pharmacol., 74, 1022-1032.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information phorbol 12-myristate 13-acetate does not increase in vitro N-SMase activity protein kinase C-delta does not regulate tumor necrosis factor-induced N-SMase activity Homo sapiens
tumor necrosis factor induces N-SMase activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
Homo sapiens 5794
-
plasma membrane phorbol 12-myristate 13-acetate induces nSMase2 translocation to the plasma membrane in a time- and dose-dependent manner, rottlerin inhibits nSMase2 translocation in response to tumor necrosis factor and phorbol 12-myristate 13-acetate Homo sapiens 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
lung epithelial cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
choline-methyl-sphingomyelin + H2O
-
Homo sapiens ?
-
?
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
N-SMase
-
Homo sapiens
neutral sphingomyelinase
-
Homo sapiens
neutral sphingomyelinase-2
-
Homo sapiens
nSMase2
-
Homo sapiens