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Literature summary for 3.1.4.12 extracted from

  • Corcoran, C.A.; He, Q.; Ponnusamy, S.; Ogretmen, B.; Huang, Y.; Sheikh, M.S.
    Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignancies (2008), Mol. Cancer Res., 6, 795-807.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information adriamycin up-regulates endogenous nSMase3 expression within 2 h that last beyond 24 h and declines to control levels by 36 h, tumor necrosis factor-alpha up-regulates endogenous nSMase3 expression within 30 min and declines to control levels by 120 min Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information prolonged treatment with adriamycin by 24 h and beyond causes a down-regulation in nSMase3 expression, activation of p53 also down-regulates nSMase3 expression Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
neutral sphingomyelinase-3
-
Homo sapiens
nSMase3
-
Homo sapiens
SKNY
-
Homo sapiens