Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | adriamycin up-regulates endogenous nSMase3 expression within 2 h that last beyond 24 h and declines to control levels by 36 h, tumor necrosis factor-alpha up-regulates endogenous nSMase3 expression within 30 min and declines to control levels by 120 min | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | prolonged treatment with adriamycin by 24 h and beyond causes a down-regulation in nSMase3 expression, activation of p53 also down-regulates nSMase3 expression | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neutral sphingomyelinase-3 | - |
Homo sapiens |
nSMase3 | - |
Homo sapiens |
SKNY | - |
Homo sapiens |