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Literature summary for 3.1.4.12 extracted from

  • Smith, E.L.; Schuchman, E.H.
    The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases (2008), FASEB J., 22, 3419-3431.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine ASM plays a complex and varied role in brain development, as well as in the pathogenesis of several common neurological diseases, ASM is particularly intriguing as an antioncogenic drug, ASM is associated with the type A Niemann-Pick disease, atherosclerosis, Wilson disease, hepatic autoimmune disease, alcohol-induced liver disease, cerebral ischemia, emphysema, cystic fibrosis, and cancer Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in CHO cells and in Mus musculus Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
D609 nonspecific sphingomyelinase inhibitor Homo sapiens
additional information desipramine is a cationic amphiphile that triggers ASM proteolysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-
membrane phosphorylation of a specific serine residue on ASM (S508) by protein kinase C-delta is required for its translocation to the cell surface Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000
-
estimated molecular weight, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens ASM is necessary for stress-induced cell death ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Homo sapiens
-
blood plasma a secreted, zinc-activated form of ASM is found in the plasma which plays an important role in the development of atherosclerosis Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ASM is necessary for stress-induced cell death Homo sapiens ?
-
?
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
-
Homo sapiens
ASM
-
Homo sapiens