Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.12 extracted from

  • Bianco, F.; Perrotta, C.; Novellino, L.; Francolini, M.; Riganti, L.; Menna, E.; Saglietti, L.; Schuchman, E.H.; Furlan, R.; Clementi, E.; Matteoli, M.; Verderio, C.
    Acid sphingomyelinase activity triggers microparticle release from glial cells (2009), EMBO J., 28, 1043-1054.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine activation of acid sphingomyelinase is necessary and sufficient for microparticle release from glial cells and define key molecular effectors of microparticle formation and IL-1beta release, thus, opening new strategies for the treatment of neuroinflammatory diseases Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibitory effect is observed in cultures treated with inhibitors of neutral SMase such as manumicyn (0.001 mM) or GW4869 (0.005 mM) Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane activated acid sphingomyelinase moves to plasma membrane outer leaflet Mus musculus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus Src kinase-dependent phosphorylation of p38 MAPK is involved in P2X7-induced A-SMase activation, A-SMase mediates ATP receptor P2X7R-dependent microparticle shedding and P2X7-dependent IL-1beta release ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
Mus musculus
-
microglia
-
Mus musculus
-
N-9 cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Src kinase-dependent phosphorylation of p38 MAPK is involved in P2X7-induced A-SMase activation, A-SMase mediates ATP receptor P2X7R-dependent microparticle shedding and P2X7-dependent IL-1beta release Mus musculus ?
-
?
sphingomyelin + H2O
-
Mus musculus N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
A-SMase
-
Mus musculus
acid sphingomyelinase
-
Mus musculus