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Literature summary for 3.1.4.12 extracted from

  • Zhang, P.; Li, B.; Gao, S.; Duan, R.D.
    Dietary sphingomyelin inhibits colonic tumorigenesis with an up-regulation of alkaline sphingomyelinase expression in ICR mice (2009), Anticancer Res., 28, 3631-3635.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
sphingomyelin dietary sphingomyelin increases the alk-Smase activity in the colon by 65%, the increased activity is associated with increased protein and mRNA expression Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
Mus musculus
-
colon adenocarcinoma cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Mus musculus N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
alk-SMase
-
Mus musculus
alkaline sphingomyelinase key enzyme responsible for sphingomyelin digestion in the gut Mus musculus