Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | many signaling molecules involved in the pathogenesis of intestinal epithelial barrier, such as TNF-alpha or IFN-gamma, may cause an alteration of the lipid composition in the cell membrane by activation of sphingomyelinases | ? | - |
? | |
sphingomyelin + H2O | Homo sapiens | exogenous sphingomyelinase causes impaired intestinal epithelial barrier function, Caco-2 cell monolayers are used as in vitro model for the intestinal barrier, exogenous sphingomyelinase increases transepithelial permeability and decreases transepithelial resistance at concentrations as low as 0.01 U/ml, overview | N-acylsphingosine + choline phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
measurement of transepithelial permeability and transepithelial resistance in Caco-2 cells, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | many signaling molecules involved in the pathogenesis of intestinal epithelial barrier, such as TNF-alpha or IFN-gamma, may cause an alteration of the lipid composition in the cell membrane by activation of sphingomyelinases | Homo sapiens | ? | - |
? | |
sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | exogenous sphingomyelinase causes impaired intestinal epithelial barrier function, Caco-2 cell monolayers are used as in vitro model for the intestinal barrier, exogenous sphingomyelinase increases transepithelial permeability and decreases transepithelial resistance at concentrations as low as 0.01 U/ml, overview | Homo sapiens | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SMase | - |
Homo sapiens |
sphingomyelinase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |