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Literature summary for 3.1.4.12 extracted from

  • Cheng, Y.; Kozubek, A.; Ohlsson, L.; Sternby, B.; Duan, R.D.
    Curcumin decreases acid sphingomyelinase activity in colon cancer Caco-2 cells (2007), Planta Med., 73, 725-730.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
curcumin inhibits acid SMase, but not neutral and alkaline SMase, in Caco-2 cells with an antiproliferative effect, the effect is more potent in monolayers than in polarised cells, metabolis effects, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Homo sapiens acid SMase is involved in colonic cancer development and apoptosis N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
Homo sapiens
-
colonic cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O acid SMase is involved in colonic cancer development and apoptosis Homo sapiens N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
acid SMase
-
Homo sapiens
acid sphingomyelinase
-
Homo sapiens
alkaline SMase
-
Homo sapiens
neutral SMase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
acid SMase assay at Homo sapiens
7
-
neutral SMase assay at Homo sapiens
9
-
alkaline SMase assay at Homo sapiens