Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amlodipine | - |
Homo sapiens | |
amlodipine | - |
Rattus norvegicus | |
astemizole | - |
Homo sapiens | |
astemizole | - |
Rattus norvegicus | |
benztropine | - |
Homo sapiens | |
benztropine | - |
Rattus norvegicus | |
bepridil | - |
Homo sapiens | |
bepridil | - |
Rattus norvegicus | |
camylofin | - |
Homo sapiens | |
camylofin | - |
Rattus norvegicus | |
chlorprothixene | - |
Homo sapiens | |
chlorprothixene | - |
Rattus norvegicus | |
clomiphene | - |
Homo sapiens | |
clomiphene | - |
Rattus norvegicus | |
cloperastine | - |
Homo sapiens | |
cloperastine | - |
Rattus norvegicus | |
cyclobenzaprine | - |
Homo sapiens | |
cyclobenzaprine | - |
Rattus norvegicus | |
cyproheptadine | - |
Homo sapiens | |
cyproheptadine | - |
Rattus norvegicus | |
doxepine | - |
Homo sapiens | |
doxepine | - |
Rattus norvegicus | |
drofenine | - |
Homo sapiens | |
drofenine | - |
Rattus norvegicus | |
fendiline | - |
Homo sapiens | |
fendiline | - |
Rattus norvegicus | |
fluoxetine | - |
Homo sapiens | |
fluoxetine | - |
Rattus norvegicus | |
maprotiline | - |
Homo sapiens | |
maprotiline | - |
Rattus norvegicus | |
additional information | ASM detachment from lysosomal membranes, caused by weak bases inhibit the enzyme, usage of structure-property-activity relation model in inhibitor screening, overview, no inhibition of ASM by dicyclomine, diphenhydramine, diphenylpyraline, donepezil, lercanidipine, mebeverine, memantine, oxymetazoline, oxyphencyclimine, pyrilamine, triprolidine, and xylometazoline | Homo sapiens | |
additional information | ASM detachment from lysosomal membranes caused by weak bases inhibit the enzyme, usage of structure-property-activity relation model in inhibitor screening, overview, no inhibition of ASM by dicyclomine, diphenhydramine, diphenylpyraline, donepezil, lercanidipine, mebeverine, memantine, oxymetazoline, oxyphencyclimine, pyrilamine, triprolidine, and xylometazoline | Rattus norvegicus | |
norfluoxetine | - |
Homo sapiens | |
norfluoxetine | - |
Rattus norvegicus | |
nortriptyline | - |
Homo sapiens | |
nortriptyline | - |
Rattus norvegicus | |
paroxetine | - |
Homo sapiens | |
paroxetine | - |
Rattus norvegicus | |
pimethixene | - |
Homo sapiens | |
pimethixene | - |
Rattus norvegicus | |
promazine | - |
Homo sapiens | |
promazine | - |
Rattus norvegicus | |
Promethazine | - |
Homo sapiens | |
Promethazine | - |
Rattus norvegicus | |
protriptyline | - |
Homo sapiens | |
protriptyline | - |
Rattus norvegicus | |
sertraline | - |
Homo sapiens | |
sertraline | - |
Rattus norvegicus | |
suloctidil | - |
Homo sapiens | |
suloctidil | - |
Rattus norvegicus | |
terfenadine | - |
Homo sapiens | |
terfenadine | - |
Rattus norvegicus | |
triflupromazine | - |
Homo sapiens | |
triflupromazine | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosomal membrane | inner lysosomal membrane, detachment caused by weak bases inhibits the enzyme | Homo sapiens | 5765 | - |
lysosomal membrane | inner lysosomal membrane, detachment caused by weak bases inhibits the enzyme | Rattus norvegicus | 5765 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | Homo sapiens | - |
N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | Rattus norvegicus | - |
N-acylsphingosine + choline phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
H4 neuroglioma cell | - |
Homo sapiens | - |
neuroglioma cell | - |
Homo sapiens | - |
PC-12 cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | - |
Rattus norvegicus | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acid sphingomyelinase | - |
Homo sapiens |
acid sphingomyelinase | - |
Rattus norvegicus |
ASM | - |
Homo sapiens |
ASM | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
7.5 | - |
assay at | Rattus norvegicus |