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Literature summary for 3.1.4.12 extracted from

  • Coll, O.; Morales, A.; Fernandez-Checa, J.C.; Garcia-Ruiz, C.
    Neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes (2007), J. Lipid Res., 48, 1924-1935.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information microinjection of the Bacillus cereus neutral sphingomyelinase in Xenopus laevis oocytes results in increased ceramide levels and triggered germinal vesicle breakdown and oxidant-dependent apoptosis, overview Bacillus cereus
additional information microinjection of the human acidic sphingomyelinase in Xenopus laevis oocytes results in increased ceramide levels and triggered germinal vesicle breakdown and oxidant-dependent apoptosis, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ NSMase is dependent on Mg2+ Bacillus cereus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens exogenous acidic sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes, which can be prevented by pre-incubation of the cells with GSH-ethyl ester, overview ?
-
?
additional information Bacillus cereus exogenous neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes, which can be prevented by pre-incubation of the cells with GSH-ethyl ester, overview ?
-
?
sphingomyelin + H2O Homo sapiens
-
N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O Bacillus cereus
-
N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Bacillus cereus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta acidic SMase Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information exogenous acidic sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes, which can be prevented by pre-incubation of the cells with GSH-ethyl ester, overview Homo sapiens ?
-
?
additional information exogenous neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes, which can be prevented by pre-incubation of the cells with GSH-ethyl ester, overview Bacillus cereus ?
-
?
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O
-
Bacillus cereus N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
acidic SMase
-
Homo sapiens
aSMase
-
Homo sapiens
bSMase
-
Bacillus cereus
hSMase
-
Homo sapiens
neutral sphingomyelinase
-
Bacillus cereus
nSMase
-
Bacillus cereus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens
37
-
assay at Bacillus cereus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
assay at Homo sapiens
7.4
-
assay at Bacillus cereus