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Literature summary for 3.1.4.12 extracted from

  • McCollister, B.D.; Myers, J.T.; Jones-Carson, J.; Voelker, D.R.; Vazquez-Torres, A.
    Constitutive acid sphingomyelinase enhances early and late macrophage killing of Salmonella enterica serovar Typhimurium (2007), Infect. Immun., 75, 5346-5352.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information extracts from ASM-deficient macrophages sustain limited enzymatic synthesis of NBD-ceramide from NBD-sphingomyelin, phenotypes of ASM-/- and ASM+/+ macrophages, intracellular survival of Salmonella enterica serovar typhimurium is enhanced in macrophages lacking ASM, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information Salmonella enterica serovar typhimurium infection reduces ASM activity, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secreted enzyme, infection of macrophages with Salmonella enterica serovar typhimurium stimulates extracellular ASM secretion Mus musculus
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Mus musculus constitutive acid sphingomyelinase enhances early and late macrophage killing of Salmonella enterica serovar typhimurium, Salmonella infection reduces ASM activity, overview N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
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heterozygous sv129 x BL/6 background mice
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Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell airway Mus musculus
-
macrophage peritoneal Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Mus musculus N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O constitutive acid sphingomyelinase enhances early and late macrophage killing of Salmonella enterica serovar typhimurium, Salmonella infection reduces ASM activity, overview Mus musculus N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
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Mus musculus
ASM
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Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
assay at Mus musculus