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Literature summary for 3.1.4.12 extracted from

  • Llacuna, L.; Mari, M.; Garcia-Ruiz, C.; Fernandez-Checa, J.C.; Morales, A.
    Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury (2006), Hepatology, 44, 561-572.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
TNFalpha activates the enzyme, which is prevented by pentoxifylline Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information ASMase knockdown by siRNA decreases ceramide generation during ischemia/reperfusion, and attenuates serum ALT levels, hepatocellular necrosis, cytochrome c release, and caspase-3 and JNK activation, ASMase down-regulation by siRNA protects the liver against ischemia/reperfusion-induced damage, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
imipramine ASMase inhibitor Mus musculus
additional information pentoxifylline treatment preventsTNFupregulation and ASMase activation Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on, ASMase Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus ASMase inhibition decreases ceramide generation during ischemia/reperfusion, and attenuates serum ALT levels, hepatocellular necrosis, cytochrome c release, and caspase-3 activation, overview, the enzyme is involved in hepatic ischemia/reperfusion damage, ceramide generated from ASMase plays a key role in I/R-induced liver damage, molecular mechanisms, overview ?
-
?
sphingomyelin + H2O Mus musculus the enzyme is important in ceramide metabolism, overview N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ASMase inhibition decreases ceramide generation during ischemia/reperfusion, and attenuates serum ALT levels, hepatocellular necrosis, cytochrome c release, and caspase-3 activation, overview, the enzyme is involved in hepatic ischemia/reperfusion damage, ceramide generated from ASMase plays a key role in I/R-induced liver damage, molecular mechanisms, overview Mus musculus ?
-
?
sphingomyelin + H2O
-
Mus musculus N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O the enzyme is important in ceramide metabolism, overview Mus musculus N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
acidic sphingomyelinase
-
Mus musculus
aSMase
-
Mus musculus