Protein Variants | Comment | Organism |
---|---|---|
additional information | aSMase silencing by siRNA in human airway epithelial cells leads to increased caspase-3 cleavage | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | exposure to the NO donors promotes an increase in the protein-protein interaction between acidic sphingomyelinase and caspase-3, with aSMase sequestering caspase-3 and preventing its cleavage and inhibiting apoptosis, overview | ? | - |
? | |
sphingomyelin + H2O | Homo sapiens | - |
N-acylsphingosine + choline phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
epithelial cell | airway | Homo sapiens | - |
HAE cell | - |
Homo sapiens | - |
HBE-1 cell | bronchial epithelial cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | exposure to the NO donors promotes an increase in the protein-protein interaction between acidic sphingomyelinase and caspase-3, with aSMase sequestering caspase-3 and preventing its cleavage and inhibiting apoptosis, overview | Homo sapiens | ? | - |
? | |
sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acidic sphingomyelinase | - |
Homo sapiens |
aSMase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.5 | - |
acidic SMase assay at | Homo sapiens |