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Literature summary for 3.1.4.12 extracted from

  • Castillo, S.S.; Levy, M.; Thaikoottathil, J.V.; Goldkorn, T.
    Reactive nitrogen and oxygen species activate different sphingomyelinases to induce apoptosis in airway epithelial cells (2007), Exp. Cell Res., 313, 2680-2686.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
H2O2 reactive oxygen species, e.g. hydrogen peroxide, specifically activate neutral sphingomyelinase 2 to generate ceramide and induce apoptosis in airway epithelial cells, overview Homo sapiens
ONOO- peroxynitrite specifically activates the acidic sphingomyelinase Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information siRNA knockdown of both nSMase2 and aSMase, silencing nSMase2 prevents H2O2-induced apoptosis, but has no effect on ONOO--induced apoptosis, while silencing of aSMase markedly impairs ONOO--induced apoptosis, but does not affect H2O2-induced apoptosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens reactive oxygen species, e.g. hydrogen peroxide, specifically activate neutral sphingomyelinase 2 to generate ceramide and induce apoptosis in airway epithelial cells, different oxidants modulate different enzymes of the ceramide generating machinery to induce apoptosis in airway epithelial cells, overview ?
-
?
sphingomyelin + H2O Homo sapiens
-
N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell airway Homo sapiens
-
HAE cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information reactive oxygen species, e.g. hydrogen peroxide, specifically activate neutral sphingomyelinase 2 to generate ceramide and induce apoptosis in airway epithelial cells, different oxidants modulate different enzymes of the ceramide generating machinery to induce apoptosis in airway epithelial cells, overview Homo sapiens ?
-
?
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
acidic sphingomyelinase
-
Homo sapiens
aSMase
-
Homo sapiens
neutral sphingomyelinase 2
-
Homo sapiens
nSMase2
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
acidic SMase Homo sapiens
7.4
-
neutral SMase Homo sapiens