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Literature summary for 3.1.4.12 extracted from

  • Duan, R.
    Sphingomyelinase and ceramidase in the intestinal tract (2007), Eur. J. Lipid Sci. Technol., 109, 987-993.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
additional information feeding psyllium, a water-soluble fiber, increases Alk-SMase and decreases N-CDase activity, and thus might enhance ceramide levels in the intestinal mucosa Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CHAPS CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase Homo sapiens
CHAPS CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase Mus musculus
CHAPS CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase Rattus norvegicus
additional information Alk-SMase is resistant to trypsin digestion Homo sapiens
additional information Alk-SMase is resistant to trypsin digestion Mus musculus
additional information Alk-SMase is resistant to trypsin digestion Rattus norvegicus
Triton X-100 CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase Homo sapiens
Triton X-100 CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase Mus musculus
Triton X-100 CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase Rattus norvegicus
Zn2+ Alk-SMase Homo sapiens
Zn2+ Alk-SMase Mus musculus
Zn2+ Alk-SMase Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Mus musculus 5886
-
plasma membrane
-
Homo sapiens 5886
-
plasma membrane
-
Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview ?
-
?
additional information Homo sapiens Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview ?
-
?
additional information Rattus norvegicus Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview ?
-
?
sphingomyelin + H2O Mus musculus Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O Rattus norvegicus Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O Homo sapiens Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview, dietary SM inhibits colonic carcinogenesis by a mechanism related to SM digestion in the gut, overview N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon high activity Mus musculus
-
colon high activity Homo sapiens
-
colon high activity Rattus norvegicus
-
colonic cancer cell
-
Mus musculus
-
colonic cancer cell
-
Homo sapiens
-
colonic cancer cell
-
Rattus norvegicus
-
gastrointestinal tract
-
Mus musculus
-
gastrointestinal tract
-
Homo sapiens
-
gastrointestinal tract
-
Rattus norvegicus
-
gut
-
Mus musculus
-
gut
-
Homo sapiens
-
gut
-
Rattus norvegicus
-
jejunum low activity Mus musculus
-
jejunum low activity Homo sapiens
-
jejunum low activity Rattus norvegicus
-
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
additional information Alk-SMase developmental enzyme activity, overview, Alk-SMase activity decreases with age Mus musculus
-
additional information Alk-SMase developmental enzyme activity, overview, Alk-SMase activity decreases with age Homo sapiens
-
additional information Alk-SMase developmental enzyme activity, overview, Alk-SMase activity decreases with age Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview Mus musculus ?
-
?
additional information Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview Homo sapiens ?
-
?
additional information Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview Rattus norvegicus ?
-
?
sphingomyelin + H2O
-
Mus musculus N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O
-
Rattus norvegicus N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview Mus musculus N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview Rattus norvegicus N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview, dietary SM inhibits colonic carcinogenesis by a mechanism related to SM digestion in the gut, overview Homo sapiens N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
acid SMase
-
Mus musculus
acid SMase
-
Homo sapiens
acid SMase
-
Rattus norvegicus
alk-SMase
-
Mus musculus
alk-SMase
-
Homo sapiens
alk-SMase
-
Rattus norvegicus
neutral SMase
-
Mus musculus
neutral SMase
-
Homo sapiens
neutral SMase
-
Rattus norvegicus
SMase
-
Mus musculus
SMase
-
Homo sapiens
SMase
-
Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
Mus musculus
9
-
-
Homo sapiens
9
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6 10.5
-
Mus musculus
6 10.5
-
Homo sapiens
6 10.5
-
Rattus norvegicus