Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | secretory sphingomyelinase is upregulated in chronic heart failure | Homo sapiens | |
TNFalpha | S-SMase cytokine TNFalpha activation, completely abrogated by desipramine, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
desipramine | inhibits acidic SMase | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | secretory sphingomyelinase S-SMase is secreted by endothelial cells upon stimulation with lipopolysaccharides and pro-inflammatory cytokines such as TNF-alpha | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | Homo sapiens | secretory sphingomyelinase is upregulated in chronic heart failure, S-SMase further correlates with reduced skeletal quadriceps muscle strength as well as impaired peripheral vasodilator capacity, physiological function and parameters of S-SMase in heart tissue, overview | N-acylsphingosine + choline phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
healthy individuals and patient with chronic heart failure | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
vascular endothelial cell | high content of S-SMase, secretion | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | secretory sphingomyelinase is upregulated in chronic heart failure, S-SMase further correlates with reduced skeletal quadriceps muscle strength as well as impaired peripheral vasodilator capacity, physiological function and parameters of S-SMase in heart tissue, overview | Homo sapiens | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acidic SMase | - |
Homo sapiens |
S-SMase | - |
Homo sapiens |
secretory sphingomyelinase | - |
Homo sapiens |