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Literature summary for 3.1.4.12 extracted from

  • Doehner, W.; Bunck, A.C.; Rauchhaus, M.; von Haehling, S.; Brunkhorst, F.M.; Cicoira, M.; Tschope, C.; Ponikowski, P.; Claus, R.A.; Anker, S.D.
    Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow (2007), Eur. Heart J., 28, 821-828.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information secretory sphingomyelinase is upregulated in chronic heart failure Homo sapiens
TNFalpha S-SMase cytokine TNFalpha activation, completely abrogated by desipramine, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
desipramine inhibits acidic SMase Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secretory sphingomyelinase S-SMase is secreted by endothelial cells upon stimulation with lipopolysaccharides and pro-inflammatory cytokines such as TNF-alpha Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Homo sapiens secretory sphingomyelinase is upregulated in chronic heart failure, S-SMase further correlates with reduced skeletal quadriceps muscle strength as well as impaired peripheral vasodilator capacity, physiological function and parameters of S-SMase in heart tissue, overview N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
healthy individuals and patient with chronic heart failure
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular endothelial cell high content of S-SMase, secretion Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O secretory sphingomyelinase is upregulated in chronic heart failure, S-SMase further correlates with reduced skeletal quadriceps muscle strength as well as impaired peripheral vasodilator capacity, physiological function and parameters of S-SMase in heart tissue, overview Homo sapiens N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
acidic SMase
-
Homo sapiens
S-SMase
-
Homo sapiens
secretory sphingomyelinase
-
Homo sapiens