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Literature summary for 3.1.4.12 extracted from

  • De Tullio, L.; Maggio, B.; Hartel, S.; Jara, J.; Fanani, M.L.
    The initial surface composition and topography modulate sphingomyelinase-driven sphingomyelin to ceramide conversion in lipid monolayers (2007), Cell Biochem. Biophys., 47, 169-177.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ceramide feedback inhibition Bacillus cereus
palmitate a non-substrate lipid belonging to the phospholipase A2 pathway Bacillus cereus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information different SMase kinetic steps are differentially regulated by non-substrate lipids, overview Bacillus cereus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Bacillus cereus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ plays a role in enzyme regulation by non-substrate lipids Bacillus cereus
Mg2+ dependent on, best at 3 mM Bacillus cereus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Bacillus cereus changes in the initial composition and topography of mixed monolayers of sphingomyelin and ceramide modulate the sphingomyelin degradation by the enzyme, overview, the enzyme in an extracellular toxin that exhibits potent hemolytic activity against sphingomyelin-rich erythrocytes in mammals N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Bacillus cereus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Bacillus cereus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O changes in the initial composition and topography of mixed monolayers of sphingomyelin and ceramide modulate the sphingomyelin degradation by the enzyme, overview, the enzyme in an extracellular toxin that exhibits potent hemolytic activity against sphingomyelin-rich erythrocytes in mammals Bacillus cereus N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O SMase shows very low activity against condensed sphingomyelin, but is active on loosely organized sphingomyelin in bilayers and monolayers, overview Bacillus cereus N-acylsphingosine + choline phosphate
-
?

Subunits

Subunits Comment Organism
More the enzyme structure and topology influences the enzyme activity, overview Bacillus cereus

Synonyms

Synonyms Comment Organism
neutral SMase
-
Bacillus cereus
SMase
-
Bacillus cereus
sphingomyelinase
-
Bacillus cereus