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Literature summary for 3.1.4.12 extracted from

  • Duan, R.D.; Verkade, H.J.; Cheng, Y.; Havinga, R.; Nilsson, A.
    Effects of bile diversion in rats on intestinal sphingomyelinases and ceramidase (2007), Biochim. Biophys. Acta, 1771, 196-201.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Bile salts required for enzyme activity, and probably to prevent enzyme dissociation from the membranes Rattus norvegicus
choline required for enzyme activity, and probably to prevent enzyme dissociation from the membranes Rattus norvegicus
taurocholate required for enzyme activity, and probably to prevent enzyme dissociation from the membranes Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information construction of nSMase2 knockout mice Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information bile diversion reduces the alkaline SMase activity by 85% in the small intestinal content and 68% in the faeces, but not in the intestinal mucosa Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane intestinal microvillar membrane Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ neutral SMase Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme is involved in sphingomyelin digestion ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
healthy and permanently bile diverted male Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
gastrointestinal tract intraluminal, intestinal microvillar membrane, and mucosa, in the intestinal tract, the activity of alkaline SMase is much higher than the activity of neutral and acid SMase, overview Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in sphingomyelin digestion Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
acid SMase
-
Rattus norvegicus
acid sphingomyelinase
-
Rattus norvegicus
alk-SMase
-
Rattus norvegicus
alkaline sphingomyelinase
-
Rattus norvegicus
intestinal sphingomyelinase
-
Rattus norvegicus
neutral SMase
-
Rattus norvegicus
neutral sphingomyelinase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
assay at, acid SMase Rattus norvegicus
7.5
-
assay at, neutral SMase Rattus norvegicus
9
-
assay at, alkaline SMase Rattus norvegicus