Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Bile salts | required for enzyme activity, and probably to prevent enzyme dissociation from the membranes | Rattus norvegicus | |
choline | required for enzyme activity, and probably to prevent enzyme dissociation from the membranes | Rattus norvegicus | |
taurocholate | required for enzyme activity, and probably to prevent enzyme dissociation from the membranes | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of nSMase2 knockout mice | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | bile diversion reduces the alkaline SMase activity by 85% in the small intestinal content and 68% in the faeces, but not in the intestinal mucosa | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | intestinal microvillar membrane | Rattus norvegicus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | neutral SMase | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | the enzyme is involved in sphingomyelin digestion | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
healthy and permanently bile diverted male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastrointestinal tract | intraluminal, intestinal microvillar membrane, and mucosa, in the intestinal tract, the activity of alkaline SMase is much higher than the activity of neutral and acid SMase, overview | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in sphingomyelin digestion | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acid SMase | - |
Rattus norvegicus |
acid sphingomyelinase | - |
Rattus norvegicus |
alk-SMase | - |
Rattus norvegicus |
alkaline sphingomyelinase | - |
Rattus norvegicus |
intestinal sphingomyelinase | - |
Rattus norvegicus |
neutral SMase | - |
Rattus norvegicus |
neutral sphingomyelinase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | - |
assay at, acid SMase | Rattus norvegicus |
7.5 | - |
assay at, neutral SMase | Rattus norvegicus |
9 | - |
assay at, alkaline SMase | Rattus norvegicus |