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Literature summary for 3.1.4.12 extracted from

  • Albi, E.; Lazzarini, R.; Viola Magni, M.
    Phosphatidylcholine/sphingomyelin metabolism crosstalk inside the nucleus (2008), Biochem. J., 410, 381-389.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylcholine-specific phospholipase C increases the N-SMase activity up to 2fold Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
D609 48% inhibition of the enzyme in chromain after 30 min of treatment, no inhibition by D609 in the nuclear membrane Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
chromatin
-
Rattus norvegicus 785
-
nuclear membrane
-
Rattus norvegicus 31965
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Rattus norvegicus
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus a phosphatidylcholine/sphingomyelin metabolism crosstalk which regulates the intranuclear ceramide/diacylglycerol pool exists in the chromatin structure, effect of phosphatidylcholine-specific phospholipase C activity on neutral sphingomyelinase and reverse sphingomyelin synthase, which enrich the intranuclear ceramide pool, overview ?
-
?
sphingomyelin + H2O Rattus norvegicus
-
N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000025
-
chromatin Rattus norvegicus
0.0009
-
nuclear membrane Rattus norvegicus
0.052
-
phospholipid pre-incubated nuclear membrane Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information a phosphatidylcholine/sphingomyelin metabolism crosstalk which regulates the intranuclear ceramide/diacylglycerol pool exists in the chromatin structure, effect of phosphatidylcholine-specific phospholipase C activity on neutral sphingomyelinase and reverse sphingomyelin synthase, which enrich the intranuclear ceramide pool, overview Rattus norvegicus ?
-
?
sphingomyelin + H2O
-
Rattus norvegicus N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
N-SMase
-
Rattus norvegicus
neutral sphingomyelinase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at, nuclear membranes Rattus norvegicus
8.4
-
assay at, chromatin Rattus norvegicus