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Literature summary for 3.1.4.12 extracted from

  • De Palma, C.; Meacci, E.; Perrotta, C.; Bruni, P.; Clementi, E.
    Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors (2006), Arterioscler. Thromb. Vasc. Biol., 26, 99-105.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information downregulation of N-SMase2 by siRNA leads to inhibition of TNFalpha-induced activation of endothelial nitric oxide synthase in the sphingomyelin and ceramide metabolism, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors are essentially involved in endothelial nitric oxide synthase activation by tumor necrosis factor alpha, regulation of the pathway, overview ?
-
?
sphingomyelin + H2O Homo sapiens
-
N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
Homo sapiens
-
endothelium
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
umbilical vein endothelial cell i.e. HUVEC Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors are essentially involved in endothelial nitric oxide synthase activation by tumor necrosis factor alpha, regulation of the pathway, overview Homo sapiens ?
-
?
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
N-SMase2
-
Homo sapiens
neutral sphingomyelinase 2
-
Homo sapiens