Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.12 extracted from

  • Takahashi, I.; Takahashi, T.; Mikami, T.; Komatsu, M.; Ohura, T.; Schuchman, E.H.; Takada, G.
    Acid sphingomyelinase: Relation of 93Lysine residue on the ratio of intracellular to secreted enzyme activity (2005), Tohoku J. Exp. Med., 206, 333-340.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
K104A mutation does not result in any altered activity Homo sapiens
K105A intracellular activity is not reduced but zinc-responsive secreted activity is reduced Homo sapiens
K118A intracellular activity is not reduced but zinc-responsive secreted activity is reduced Homo sapiens
K124A intracellular activity is not reduced but zinc-responsive secreted activity is reduced Homo sapiens
K183A intracellular activity is not reduced but zinc-responsive secreted activity is reduced Homo sapiens
K187A intracellular activity is reduced but zinc-responsive secreted activity is unchanged Homo sapiens
K249A intracellular activity and zinc-responsive secreted activity are both reduced Homo sapiens
K305A intracellular activity and zinc-responsive secreted activity are both reduced Homo sapiens
K346A intracellular activity is reduced but zinc-responsive secreted activity is unchanged Homo sapiens
K419A intracellular activity and zinc-responsive secreted activity are both reduced Homo sapiens
K433A intracellular activity and zinc-responsive secreted activity are both reduced Homo sapiens
K576A intracellular activity and zinc-responsive secreted activity are both reduced Homo sapiens
K93A mutant enzyme has reduced intracellular activity, but enhanced zinc-responsive secreted activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-
intracellular the ratio of secreted to intracellular activity is about 8fold greater in I-cells (skin fibroblasts from I-cell disease patients, in which one of the enzymes responsible for mannose phosphorylation, GlcNAc-phosphotransferase, is deficient) than in normal cells Homo sapiens 5622
-
lysosome can rapidly move from lysosomes to cell surface upon stimulation by cytokines and other factors Homo sapiens 5764
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ most of the secreted activity requires Zn2+ for full activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens an inherited deficiency of this enzymatic activity results in the type A and B forms of Niemann-Pick disease ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein mannose phosphorylation is important in the trafficking of this enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information an inherited deficiency of this enzymatic activity results in the type A and B forms of Niemann-Pick disease Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
acid spingomyelinase
-
Homo sapiens