Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | age-related decreases in the hippocampal and striatal cytosolic N-Sase activities are accompanied by increases in the membrane N-Sase activities | Rattus norvegicus | 5829 | - |
membrane | age-related decreases in the hippocampal and striatal cytosolic N-Sase activities are accompanied by increases in the membrane N-Sase activities. Significant increase in cortical membrane-associated N-Sase activity with age | Rattus norvegicus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | key enzyme of sphingolipid metabolism and sphingolipid-induced signaling. The enzyme is a contributor to the increased stress and inflammatory sensitivity amoung the brain regions with age | ? | - |
? | |
additional information | Rattus norvegicus Fischer 344 | key enzyme of sphingolipid metabolism and sphingolipid-induced signaling. The enzyme is a contributor to the increased stress and inflammatory sensitivity amoung the brain regions with age | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Fischer 344 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebellar cortex | in hippocampus the enzyme activity is significantly higher than in striatum and cortex. Significant increase in cortical membrane-associated N-Sase activity with age | Rattus norvegicus | - |
corpus striatum | in hippocampus the enzyme activity is significantly higher than in striatum and cortex. Age-related decreases in the hippocampal and striatal cytosolic N-Sase activities are accompanied by increases in the membrane N-Sase activities | Rattus norvegicus | - |
hippocampus | in hippocampus the enzyme activity is significantly higher than in striatum and corte. Age-related decreases in the hippocampal and striatal cytosolic N-Sase activities are accompanied by increases in the membrane N-Sase activities | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | key enzyme of sphingolipid metabolism and sphingolipid-induced signaling. The enzyme is a contributor to the increased stress and inflammatory sensitivity amoung the brain regions with age | Rattus norvegicus | ? | - |
? | |
additional information | key enzyme of sphingolipid metabolism and sphingolipid-induced signaling. The enzyme is a contributor to the increased stress and inflammatory sensitivity amoung the brain regions with age | Rattus norvegicus Fischer 344 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ceramide-phosphocholine phosphodiesterase | - |
Rattus norvegicus |
N-Sase | - |
Rattus norvegicus |
neutral sphingomyelin-specific phospholipase C | - |
Rattus norvegicus |