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Literature summary for 3.1.4.12 extracted from

  • Crivello, N.A.; Rosenberg, I.H.; Dallal, G.E.; Bielinski, D.; Joseph, J.A.
    Age-related changes in neutral sphingomyelin-specific phospholipase C activity in striatum, hippocampus, and frontal cortex: implication for sensitivity to stress and inflammation (2005), Neurochem. Int., 47, 573-579.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol age-related decreases in the hippocampal and striatal cytosolic N-Sase activities are accompanied by increases in the membrane N-Sase activities Rattus norvegicus 5829
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membrane age-related decreases in the hippocampal and striatal cytosolic N-Sase activities are accompanied by increases in the membrane N-Sase activities. Significant increase in cortical membrane-associated N-Sase activity with age Rattus norvegicus 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus key enzyme of sphingolipid metabolism and sphingolipid-induced signaling. The enzyme is a contributor to the increased stress and inflammatory sensitivity amoung the brain regions with age ?
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?
additional information Rattus norvegicus Fischer 344 key enzyme of sphingolipid metabolism and sphingolipid-induced signaling. The enzyme is a contributor to the increased stress and inflammatory sensitivity amoung the brain regions with age ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Rattus norvegicus Fischer 344
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-
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Source Tissue

Source Tissue Comment Organism Textmining
cerebellar cortex in hippocampus the enzyme activity is significantly higher than in striatum and cortex. Significant increase in cortical membrane-associated N-Sase activity with age Rattus norvegicus
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corpus striatum in hippocampus the enzyme activity is significantly higher than in striatum and cortex. Age-related decreases in the hippocampal and striatal cytosolic N-Sase activities are accompanied by increases in the membrane N-Sase activities Rattus norvegicus
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hippocampus in hippocampus the enzyme activity is significantly higher than in striatum and corte. Age-related decreases in the hippocampal and striatal cytosolic N-Sase activities are accompanied by increases in the membrane N-Sase activities Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information key enzyme of sphingolipid metabolism and sphingolipid-induced signaling. The enzyme is a contributor to the increased stress and inflammatory sensitivity amoung the brain regions with age Rattus norvegicus ?
-
?
additional information key enzyme of sphingolipid metabolism and sphingolipid-induced signaling. The enzyme is a contributor to the increased stress and inflammatory sensitivity amoung the brain regions with age Rattus norvegicus Fischer 344 ?
-
?

Synonyms

Synonyms Comment Organism
ceramide-phosphocholine phosphodiesterase
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Rattus norvegicus
N-Sase
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Rattus norvegicus
neutral sphingomyelin-specific phospholipase C
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Rattus norvegicus