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Literature summary for 3.1.4.12 extracted from

  • Soeda, S.; Tsuji, Y.; Ochiai, T.; Mishima, K.; Iwasaki, K.; Fujiwara, M.; Yokomatsu, T.; Murano, T.; Shibuya, S.; Shimeno, H.
    Inhibition of sphingomyelinase activity helps to prevent neuron death caused by ischemic stress (2004), Neurochem. Int., 45, 619-626.
    View publication on PubMed

Application

Application Comment Organism
medicine inhibiting or stopping N-SMase activity is an important strategy to prevent neuron death from ischemia Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
[(2S)-1,1-difluoro-3-(hexadecanoylamino)-2,4-dihydroxy-4-phenylbutyl]phosphonic acid SMA-3
-
Rattus norvegicus
[(4S)-1,1-difluoro-3-(hexadecanoylamino)-4-hydroxy-4-phenylbutyl]phosphonic acid
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus neutral sphingomyelinase is a key component of the signaling pathway in cytokine- and other stress-induced cellular responses ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-12 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information neutral sphingomyelinase is a key component of the signaling pathway in cytokine- and other stress-induced cellular responses Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
N-SMase
-
Rattus norvegicus
neutral sphingomyelinase
-
Rattus norvegicus