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Literature summary for 3.1.4.12 extracted from

  • Testai, F.D.; Landek, M.A.; Goswami, R.; Ahmed, M.; Dawson, G.
    Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl-myo-inositol 3,4,5-triphosphate in oligodendrocyte cell signaling (2004), J. Neurochem., 89, 636-644.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3',5'-cAMP IC50: above 0.5 mM Homo sapiens
5-adenoylimino phosphate IC50: above 0.5 mM Homo sapiens
adeno 5'-diphosphate IC50: above 0.5 mM Homo sapiens
adeno-2',3'-cyclic phospho 5'-monophosphate IC50: 0.2 mM Homo sapiens
adeno-2',3'-cyclic phospho 5'-phosphosulfate IC50: 0.5 mM Homo sapiens
ADP IC50: 0.3 mM Homo sapiens
AMP IC50: 0.08 mM, non-competitive inhibition Homo sapiens
ATP IC50: 0.8 mM Homo sapiens
lysophosphatidic acid IC50: 0.04 mM Homo sapiens
NAD+ IC50: above 0.5 mM Homo sapiens
NADP+ IC50: above 0.5 mM Homo sapiens
phosphate IC50: 10 mM, non-competitive inhibition Homo sapiens
phosphatidyl-myo-inositol 3,4,5-triphosphate IC50: 0.003 mM Homo sapiens
phosphatidyl-myo-inositol 4,5-diphosphate IC50: 0.25 mM Homo sapiens
phosphatidylcholine IC50: 2 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HOG cell human oligodendroglioma cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-hexadecanoylamino-4-methylumbelliferyl-phosphocholine + H2O
-
Homo sapiens 6-hexadecanoylamino-4-methylumbelliferone + choline phosphate
-
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Synonyms

Synonyms Comment Organism
aSMase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.003
-
IC50: 0.003 mM Homo sapiens phosphatidyl-myo-inositol 3,4,5-triphosphate
0.04
-
IC50: 0.04 mM Homo sapiens lysophosphatidic acid
0.08
-
IC50: 0.08 mM, non-competitive inhibition Homo sapiens AMP
0.2
-
IC50: 0.2 mM Homo sapiens adeno-2',3'-cyclic phospho 5'-monophosphate
0.25
-
IC50: 0.25 mM Homo sapiens phosphatidyl-myo-inositol 4,5-diphosphate
0.3
-
IC50: 0.3 mM Homo sapiens ADP
0.5
-
IC50: 0.5 mM Homo sapiens adeno-2',3'-cyclic phospho 5'-phosphosulfate
0.5
-
IC50: above 0.5 mM Homo sapiens NAD+
0.5
-
IC50: above 0.5 mM Homo sapiens NADP+
0.5
-
IC50: above 0.5 mM Homo sapiens 3',5'-cAMP
0.5
-
IC50: above 0.5 mM Homo sapiens adeno 5'-diphosphate
0.5
-
IC50: above 0.5 mM Homo sapiens 5-adenoylimino phosphate
0.8
-
IC50: 0.8 mM Homo sapiens ATP
2
-
IC50: 2 mM Homo sapiens phosphatidylcholine
10
-
IC50: 10 mM, non-competitive inhibition Homo sapiens phosphate