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Literature summary for 3.1.4.12 extracted from

  • Krut, O.; Wiegmann, K.; Kashkar, H.; Yazdanpanah, B.; Kronke, M.
    Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein (2006), J. Biol. Chem., 281, 13784-13793.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information tumor necrosis factor stimulates rapid activation of nSMase3 in MCF7 cells with peak activity at 1.5 min Homo sapiens
phosphatidylserine enhances activity Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Saccharomyces cerevisiae strain JK9-3dDELTAIsc1p, lacking endogenous SMase activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
scyphostatin
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01871
-
sphingomyelin
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-
Golgi apparatus
-
Homo sapiens 5794
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 5 mM, stimulates Homo sapiens
Mn2+ 5 mM, stimulates Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NXE4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
neutral sphingomyelinase-3
-
Homo sapiens
nSMase3
-
Homo sapiens
SMPD4
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Homo sapiens