Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | tumor necrosis factor stimulates rapid activation of nSMase3 in MCF7 cells with peak activity at 1.5 min | Homo sapiens | |
phosphatidylserine | enhances activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression in Saccharomyces cerevisiae strain JK9-3dDELTAIsc1p, lacking endogenous SMase activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
scyphostatin | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01871 | - |
sphingomyelin | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Golgi apparatus | - |
Homo sapiens | 5794 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | 5 mM, stimulates | Homo sapiens | |
Mn2+ | 5 mM, stimulates | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NXE4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neutral sphingomyelinase-3 | - |
Homo sapiens |
nSMase3 | - |
Homo sapiens |
SMPD4 | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Homo sapiens |