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Literature summary for 3.1.4.12 extracted from

  • Koelzer, M.; Werth, N.; Sandhoff, K.
    Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine (2004), FEBS Lett., 559, 96-98.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information the tricyclic antidepressant desipramine possibly induces intracellular proteolysis of A-SMase by displacing the enzyme from its membrane-bound lipid substrate and thereby making it sensitive to proteolysis. The resulting loss of lysosomal A-SMase activity may well trigger the lysosomal lipid accumulation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
A-SMase
-
Homo sapiens
acid sphingomyelinase
-
Homo sapiens