Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the tricyclic antidepressant desipramine possibly induces intracellular proteolysis of A-SMase by displacing the enzyme from its membrane-bound lipid substrate and thereby making it sensitive to proteolysis. The resulting loss of lysosomal A-SMase activity may well trigger the lysosomal lipid accumulation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
A-SMase | - |
Homo sapiens |
acid sphingomyelinase | - |
Homo sapiens |