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Literature summary for 3.1.4.12 extracted from
- Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging (2005), Exp. Dermatol., 14, 609-618.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sphingomyelin + H2O | Mus musculus | A-SMase in the outer epidermis is essential for basal permeability function, A-SMase activity in the lower epidermis is involved in basal permeability barrier homeostasis | N-acylsphingosine + choline phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epidermis | unchanged A-SMase activity in the outer epidermis of chronologically aged skin, in the lower epidermis the activity is reduced | Mus musculus | - |
| skin | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sphingomyelin + H2O | A-SMase in the outer epidermis is essential for basal permeability function, A-SMase activity in the lower epidermis is involved in basal permeability barrier homeostasis | Mus musculus | N-acylsphingosine + choline phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| A-SMase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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