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Literature summary for 3.1.4.12 extracted from

  • Contreras, F.X.; Sot, J.; Ruiz-Arguello, M.B.; Alonso, A.; Goni, F.M.
    Cholesterol modulation of sphingomyelinase activity at physiological temperatures (2004), Chem. Phys. Lipids, 130, 127-134.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cholesterol sphingomyelinase activity is higher in the cholesterol-induced liquid-ordered phase than in the gel phase Bacillus cereus

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Bacillus cereus cholesterol activation of sphingomyelinase and the strong affinity of cholesterol for sphingomyelin allows the rapid, localized and self-contained production of the metabolic signal ceramide in specific microdomains N-acylsphingosine + choline phosphate
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Organism

Organism UniProt Comment Textmining
Bacillus cereus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
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Bacillus cereus N-acylsphingosine + choline phosphate
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?
sphingomyelin + H2O cholesterol activation of sphingomyelinase and the strong affinity of cholesterol for sphingomyelin allows the rapid, localized and self-contained production of the metabolic signal ceramide in specific microdomains Bacillus cereus N-acylsphingosine + choline phosphate
-
?