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Literature summary for 3.1.4.12 extracted from

  • Wu, J.; Cheng, Y.; Nilsson, A.; Duan, R.D.
    Identification of one exon deletion of intestinal alkaline sphingomyelinase in colon cancer HT-29 cells and a differentiation-related expression of the wild-type enzyme in Caco-2 cells (2004), Carcinogenesis, 25, 1327-1333.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
enzyme expressed from cDNA from HT-29 cells in COS-7 cells shows little alk-SMase activity, enzyme expressed from cDNA from Caco-2 cells in COS-7 cells is as active as wild-type enzyme Homo sapiens

Protein Variants

Protein Variants Comment Organism
H353A inactive mutant enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell no mutation identified Homo sapiens
-
HT-29 cell deletion of exon 4 in alk-SMase cDNA Homo sapiens
-

Synonyms

Synonyms Comment Organism
alk-SMase
-
Homo sapiens