Activating Compound | Comment | Organism | Structure |
---|---|---|---|
saposin C | presence of sphingolipid activator proteins, e. g. saponsins, is not essential for activity. Saposin C increases activity of the P153A mutant enzyme, but does not result in complete restoration of the activity | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C120S | mutant enzyme is almost completely devoid of activity in the detergent-containing micellar assay system as well as in the liposomal assay system in the presence of saposin C | Homo sapiens |
C131S | mutant enzyme is almost completely devoid of activity in the detergent-containing micellar assay system as well as in the liposomal assay system in the presence of saposin C | Homo sapiens |
K118E | mutant enzyme is almost completely devoid of activity in the detergent-containing micellar assay system as well as in the liposomal assay system in the presence of saposin C | Homo sapiens |
O153A | mutant enzyme still exhibits enzyme activity of approximately 52% of normal in a detergent-containing micellar assay, but only 13% of normal activity in a detergent-free liposomal assay system. Addition of saposin C to the liposomal ass mixture increases activity of the mutant enzyme to 46% of normal. Saposin C does not result in complete restoration of the variant activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | the sap-like domain of human acid sphingomyelinase has activator-like functions, as well as importance as an integral part of acid spingomyelinase required for normal enzyme activity | Homo sapiens | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
A-SMase | - |
Homo sapiens |
acid sphingomyelinase | - |
Homo sapiens |