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Literature summary for 3.1.4.12 extracted from

  • Duan, R.D.
    Alkaline sphingomyelinase: An old enzyme with novel implications (2006), Biochim. Biophys. Acta, 1761, 281-291.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Homo sapiens the enzyme is down regulated in human long-standing ulcerative colitis and colonic adenocarcinoma. Mutations of the enzyme found in colon cancer cells. IN the small intestine, alk-SMase is the key enzyme for sphingomyelin digestion. The hydrolysis of sphingomyelin may affect the cholesterol uptake and have impact on sphingomyelin levels in plasma lipoproteins N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bile
-
Homo sapiens
-
colonic adenocarcinoma cell the enzyme is down regulated in human long-standing ulcerative colitis and colonic adenocarcinoma Homo sapiens
-
colonic cancer cell mutation of the enzyme found in Homo sapiens
-
intestine the enzyme is down regulated in human long-standing ulcerative colitis and colonic adenocarcinoma Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O the enzyme is down regulated in human long-standing ulcerative colitis and colonic adenocarcinoma. Mutations of the enzyme found in colon cancer cells. IN the small intestine, alk-SMase is the key enzyme for sphingomyelin digestion. The hydrolysis of sphingomyelin may affect the cholesterol uptake and have impact on sphingomyelin levels in plasma lipoproteins Homo sapiens N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
alk-SMase
-
Homo sapiens