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Literature summary for 3.1.4.12 extracted from

  • Wu, J.; Hansen, G.H.; Nilsson, A.; Duan, R.D.
    Functional studies of human intestinal alkaline sphingomyelinase by deglycosylation and mutagenesis (2005), Biochem. J., 386, 153-160.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C78N reduced alk-SMase activity Homo sapiens
M74K reduced alk-SMase activity Homo sapiens
S76F alk-SMase activity is abolished Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Homo sapiens 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein the five potential N-glycosylation sites are all glycosylated, activity of the enzyme is severely affected by defective N-glycosylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
alk-SMase
-
Homo sapiens
alkaline sphingomyelinase
-
Homo sapiens