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Literature summary for 3.1.4.12 extracted from

  • Itoh, F.S.; Yoshida, A.; Higashi, S.; Ikezawa, H.; Ikeda, K.
    Activation of sphingomyelinase from Bacillus cereus by Zn2+ hitherto accepted as a strong inhibitor (2005), Arch. Biochem. Biophys., 43, 227-236.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
Zn2+ the enzyme possesses at least two different binding sites for Zn2+. Zn2+ binding to the high affinity site can activate the enzyme, whereas the Zn2+ binding to the low-affinity site can activate the enzyme. Binding of the substrate to the enzyme is independent of the Zn2+ binding to the high-affinity site, but is competitively inhibited by the Zn2+ binding to the low-affinity site. Rank-order of increasing activation: Mg2+, Co2+, Mn2+, Zn2+. The four metal ions compete with each other for the same binding site on the enzyme molecule Bacillus cereus

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ rank-order of increasing activation: Mg2+, Co2+, Mn2+, Zn2+. The four metal ions compete with each other for the same binding site on the enzyme molecule Bacillus cereus
Mg2+ rank-order of increasing activation: Mg2+, Co2+, Mn2+, Zn2+. The four metal ions compete with each other for the same binding site on the enzyme molecule Bacillus cereus
Mn2+ rank-order of increasing activation: Mg2+, Co2+, Mn2+, Zn2+. The four metal ions compete with each other for the same binding site on the enzyme molecule Bacillus cereus
Zn2+ rank-order of increasing activation: Mg2+, Co2+, Mn2+, Zn2+. The four metal ions compete with each other for the same binding site on the enzyme molecule Bacillus cereus
Zn2+ the enzyme possesses at least two different binding sites for Zn2+. Zn2+ binding to the high affinity site can activate the enzyme, whereas the Zn2+ binding to the low-affinity site can activate the enzyme. Binding of the substrate to the enzyme is independent of the Zn2+ binding to the high-affinity site, but is competitively inhibited by the Zn2+ binding to the low-affinity site. Rank-order of increasing activation: Mg2+, Co2+, Mn2+, Zn2+. The four metal ions compete with each other for the same binding site on the enzyme molecule Bacillus cereus

Organism

Organism UniProt Comment Textmining
Bacillus cereus
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Synonyms

Synonyms Comment Organism
SMase
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Bacillus cereus