Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dioleoyl-phosphatidylserine | 0.05 mM, 4fold activation | Homo sapiens | |
phosphatidylethanol | 0.05 mM, 2fold activation | Homo sapiens | |
phosphatidylserine | 0.05 mM, 4fold activation | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cloning of cDNA | Homo sapiens |
cloning of cDNA, expression in HEK293 kidney cells | Mus musculus |
General Stability | Organism |
---|---|
reducing agents such as dithiothreitol stablize nSMase2 during preparation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | 5 mM, complete inhibition, activity is comletely restored by the subsequent addition of 10 mM Mg2+ or Mn2+ | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required for activity | Homo sapiens | |
Mn2+ | can replace Mn2+ | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
71000 | - |
x * 71000, deduced from nucleotide sequence | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | Homo sapiens | - |
N-acylsphingosine + choline phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NY59 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 71000, deduced from nucleotide sequence | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
neutral sphingomyelinase 2 | - |
Homo sapiens |
neutral sphingomylinase 2 | - |
Homo sapiens |
nSMase2 | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.5 | 9 | approx. 5% of maximal activity at pH 4.5, approx. 15% of maximal activity at pH 9.0 | Homo sapiens |