Activating Compound | Comment | Organism | Structure |
---|---|---|---|
1-oleoyl-rac-glycerol | approx. 20% stimulation at 0.4-0.8 mM, inhibition above | Rattus norvegicus | |
1-stearoyl-rac-glycerol | approx. 10% stimulation at 0.8 mM, inhibition above | Rattus norvegicus | |
arachidonic acid | approx. 20% stimulation at 0.4-0.8 mM, inhibition above | Rattus norvegicus | |
linoleic acid | approx. 20% stimulation at 0.8 mM, inhibition above | Rattus norvegicus | |
linolenic acid | approx. 30% stimulation at 0.8-1.6 mM, inhibition above | Rattus norvegicus | |
oleic acid | approx. 40% stimulation at 0.8 mM, inhibition above | Rattus norvegicus | |
stearic acid | approx. 20% stimulation at 0.4-0.8 mM, inhibition above | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2-dioleoyl-sn-glycerol | approx. 40% inhibition at 3.2 mM | Rattus norvegicus | |
1,2-distearoyl-rac-glycerol | approx. 30% inhibition at 3.2 mM | Rattus norvegicus | |
1-oleoyl-rac-glycerol | slight stimulation below 0.8 mM, approx. 50% inhibition at 3.2 mM | Rattus norvegicus | |
1-stearoyl-rac-glycerol | slight stimulation below 0.8 mM, approx. 10% inhibition at 3.2 mM | Rattus norvegicus | |
arachidonic acid | slight stimulation below 0.8 mM, approx. 50% inhibition at 3.2 mM | Rattus norvegicus | |
ceramide | strong inhibition in the presence of 0.4 mM linoleic acid | Rattus norvegicus | |
cholesterol | strong inhibition in the presence of 0.4 mM linoleic acid | Rattus norvegicus | |
linoleic acid | slight stimulation below 0.8 mM, approx. 45% inhibition at 3.2 mM | Rattus norvegicus | |
linolenic acid | stimulation below 0.8 mM, approx. 15% inhibition at 3.2 mM | Rattus norvegicus | |
oleic acid | stimulation below 0.8 mM, approx. 10% inhibition at 3.2 mM | Rattus norvegicus | |
stearic acid | slight stimulation below 0.8 mM, approx. 10% inhibition at 3.2 mM | Rattus norvegicus | |
triolein | approx. 30% inhibition at 3.2 mM | Rattus norvegicus | |
tristearin | approx. 35% inhibition at 3.2 mM | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | Rattus norvegicus | - |
N-acylsphingosine + choline phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | - |
Rattus norvegicus | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alkaline SMase | - |
Rattus norvegicus |
alkaline sphingomyelinase | - |
Rattus norvegicus |