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Literature summary for 3.1.4.12 extracted from

  • Cheng, Y.; Nilsson, A.; Tomquist, E.; Duan, R.D.
    Purification, characterization, and expression of rat intestinal alkaline sphingomyelinase (2002), J. Lipid Res., 43, 316-324.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
taurochenodeoxycholate strong activation, maximal activation at approx. 2 mM Rattus norvegicus
taurocholate strong activation, maximal activation at approx. 10 mM Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
dithiothreitol 10 mM, 25% inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.25
-
sphingomyelin 37°C, pH 9.0 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
x * 58000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Rattus norvegicus
-
N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
acetone, DEAE-Sepharose, High Q, Phenyl-Sepharose, SE-column Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
14.8
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + H2O 8% of activity with sphingomyelin Rattus norvegicus diacylglycerol + choline phosphate
-
?
sphingomyelin + H2O
-
Rattus norvegicus N-acylsphingosine + choline phosphate
-
?

Subunits

Subunits Comment Organism
? x * 58000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
alkaline SMase
-
Rattus norvegicus
alkaline sphingomyelinase
-
Rattus norvegicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
no loss of activity after 1 h Rattus norvegicus
60
-
complete loss of activity Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9 9.5
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6 10 almost no activity at pH 6.0, approx. 60% of maximal activity at pH 7.5, approx. 90% of maximal activity at Ph 10.0 Rattus norvegicus