Cloned (Comment) | Organism |
---|---|
expression in MCF7 breast cancer cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | nSMase2 is distributed thoughout the cells in subconfluent, proliferating cultures | Homo sapiens | - |
- |
plasma membrane | nSMase2 is nearly exclusively located at the plasma membrane in confluent, contact-inhibited cells | Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | nSMase2 functions as a growth suppressor in MCF-7 cells, linking confluence to the G0/G1 cell cycle check point | ? | - |
? | |
sphingomyelin + H2O | Homo sapiens | - |
N-acylsphingosine + choline phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | - |
nSMase2 expression is up-regulated during cell growth | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | endogenous nSMase2 mRNA is upregulated 5fold when MCF-7 cells become growth-arrested at confluence, and total neutral SMase is increased 119% with respect to subconfluent cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | nSMase2 functions as a growth suppressor in MCF-7 cells, linking confluence to the G0/G1 cell cycle check point | Homo sapiens | ? | - |
? | |
sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neutral sphingomyelinase 2 | - |
Homo sapiens |
nSMase2 | - |
Homo sapiens |