Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.12 extracted from

  • Marchesini, N.; Luberto, C.; Hannun, Y.A.
    Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism (2003), J. Biol. Chem., 278, 13775-13783.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cardiolipin 0.1 mM, approx. 40fold activation Mus musculus
phosphatidylserine 0.1-0.15 mM, approx. 40fold activation Mus musculus
Triton X-100 required for activity, maximal activation at 0.1% Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of nSMase2 in Saccharomyces cerevisiae and MCF7 breast cancer cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
GW4869 0.015 mM, 40% inhibition, 0.045 mM, 70% inhibition Mus musculus
Mn2+ slight inhibition above 2 mM Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.027
-
sphingomyelin 37°C, pH 7.4, recombinant nSMase2 in yeast microsomes Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for activity, maximal activation at 5 mM Mus musculus
Mn2+ can replace Mg2+, maximal activation at 1-2 mM, slight inhibition above Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Mus musculus
-
N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JJY3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Mus musculus N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
neutral sphingomyelinase
-
Mus musculus
nSMase2
-
Mus musculus