Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphatidylserine | 0.2 mM, approx. 108fold activation of sphingomyelin hydrolysis in the presence of 0.1% Triton X-100 | Homo sapiens | |
Triton X-100 | 0.1%, approx. 108fold activation of sphingomyelin hydrolysis in the presence of 0.2 mM phosphatidylserine | Homo sapiens | |
Triton X-100 | 0.1%, approx. 61fold activation of sphingomyelin hydrolysis in the presence of 0.2 mM phosphatidylserine | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Bacillus cereus |
expression of nSMase1 in HEK293 kidney cells | Homo sapiens |
expression of nSMase2 in HEK293 kidney cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | Homo sapiens | - |
N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | Bacillus cereus | - |
N-acylsphingosine + choline phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus cereus | - |
- |
- |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant SMase | Bacillus cereus |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.46 | - |
sphingosylphosphocholine hydrolysis | Bacillus cereus |
0.49 | - |
sphingomyelin hydrolysis | Bacillus cereus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lyso-platelet-activating factor + H2O | 103fold higher activity than with sphingomyelin in the absence of detergent | Homo sapiens | 1-alkylglycerol + choline phosphate | - |
? | |
lyso-platelet-activating factor + H2O | 55% of activity with sphingomyelin in the absence of detergent | Homo sapiens | alkylglycerol + choline phosphate | - |
? | |
lysophosphatidylcholine + H2O | 198fold higher activity than with sphingomyelin in the absence of detergent | Homo sapiens | acylglycerol + choline phosphate | - |
? | |
lysophosphatidylcholine + H2O | 580% of activity with sphingomyelin in the absence of detergent | Homo sapiens | acylglycerol + choline phosphate | - |
? | |
sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | - |
Bacillus cereus | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | very low activity in the absence of detergent | Homo sapiens | N-acylsphingosine + choline phosphate | - |
? | |
sphingosylphosphocholine + H2O | - |
Bacillus cereus | sphingosine + choline phosphate | - |
? | |
sphingosylphosphocholine + H2O | 127fold higher activity than with sphingomyelin in the absence of detergent | Homo sapiens | sphingosine + choline phosphate | - |
? | |
sphingosylphosphocholine + H2O | 980% of activity with sphingomyelin in the absence of detergent | Homo sapiens | sphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neutral sphingomyelinase | - |
Homo sapiens |
neutral sphingomyelinase | - |
Bacillus cereus |
nSMase | - |
Bacillus cereus |
nSMase1 | - |
Homo sapiens |
nSMase2 | - |
Homo sapiens |